Publications from the Shaw Lab, listed by year.
View the complete publication list on PubMed: Dr. Robin M. Shaw
2025
Baum, Rachel; Nguyen, Vu D; Maalouf, Mario; Shimura, Daisuke; Waghalter, Miriam; Srapyan, Sargis; Jin, Qianru; Kuzmanovich, Lucas; Gaffney, Adelaide T; Bell, Bridger R; Xiao, Shaohua; Palatinus, Joseph A; Kléber, André G; Grintsevich, Elena E; Hong, TingTing; Shaw, Robin M. A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43. J Cell Biol, vol. 224, no. 3, 2025.
2024
Li, Jing; Balmaceda, Pia; Ha, Thuy; Visker, Joseph R; Maalouf, Nicole; Kwan, Eugene; Hoareau, Guillaume L; Accad, Michel; Ranjan, Ravi; Selzman, Craig H; Drakos, Stavros G; Shaw, Robin M; Hong, TingTing. Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs. NPJ Regen Med, vol. 9, no. 1, pp. 36, 2024.
Jin, Qianru; Lee, Keel Yong; Selimi, Zoja; Shimura, Daisuke; Wang, Ethan; Zimmerman, John F; Shaw, Robin M; Kucera, Jan P; Parker, Kevin Kit; Saffitz, Jeffrey E; Kleber, Andre G. Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy. J Mol Cell Cardiol, vol. 186, pp. 71–80, 2024.
2023
Li, Jing; Richmond, Bradley; Cluntun, Ahmad A; Bia, Ryan; Walsh, Maureen A; Shaw, Kikuyo; Symons, J David; Franklin, Sarah; Rutter, Jared; Funai, Katsuhiko; Shaw, Robin M; Hong, TingTing. Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose. JCI Insight, vol. 8, no. 18, 2023.
Hogen, Talli; Li, Jing; Balmaceda, Pia; Ha, Thuy; Brown, Greg W; Shaw, Robin M; Hong, TingTing. Echocardiography Recording in Awake Miniature Pigs. J Vis Exp, no. 195, 2023.
Palatinus, Joseph A; Valdez, Steven; Taylor, Lindsey; Whisenant, Claire; Selzman, Craig H; Drakos, Stavros G; Ranjan, Ravi; Hong, TingTing; Saffitz, Jeffrey E; Shaw, Robin M. GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy. Circ Res, vol. 132, no. 6, pp. 744–746, 2023.
2022
Shimura D, Shaw RM. GJA1-20k and Mitochondrial Dynamics. Front. Physiol., vol. 13: 867358, 2022.
Shimura D; Hunter J; Katsumata M, Shaw RM. Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein. J Vis Exp (JoVE), no. (181): e63405, 2022.
2021
Khan MS, Shaw RM. Huntington’s disease skeletal muscle has altered T-tubules. JGP Journal of General Physiology, 2021.
Shimura D; Neubel E; Baum R; Valdez SE; Xiao X; Warren JS; Palatinus JA; Hong T; Rutter J, Shaw RM. Protective mitochondrial fission induced by stress responsive protein GJA1-20k. eLife, vol. 10: e69207, 2021.
Shaw RM, Saffitz JE. A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. J Clin Invest, vol. 130(4), 1608-1610, 2021.
Shaw RM. Ion Channel Trafficking in the Heart. CARDIAC ELECTROPHYSIOLOGY, 2021.
Wei J; Pacheco C, Shufelt C. Association of coronary microvascular dysfunction and cardiac bridge integrator 1, a cardiomyocyte dysfunction biomarker. 2021.
2020
TC, Hitzeman; Y, Xie; RH, Zadikany; AP, Nikolova; R, Baum; B, Xu; S, Agvanian; GY, Melmed; DT, McGovern; DR, Geft; DH, Chang; JD, Moriguchi; A, Hage; B, Azarbal; LS, Czer; MM, Kittleson; JK, Patel; AHB, Wu; JA, Kobashigawa; M, Hamilton; TT, Hong; RM, Shaw. cBIN1 Score (CS) identifies ambulatory HFrEF patients and predicts cardiovascular events. Front Physiology, vol. 11, no. 503, 2020.
Xiao, S; D, Shimura; R, Baum; DM, Hernandez; S, Agvanian; Y, Nagaoka; M, Katsumata; PD, Lampe; AG, Kleber; T, Hong; RM, Shaw. Auxiliary Trafficking Subunit GJA1-20k Protects Connexin43 from Degradation and Limits Ventricular Arrhythmias. JCI, 2020.
Y, Liu; K, Zhou; J, Li; S, Agvanian; A, Caldaruse; S, Shaw; TC, Hitzeman; RM, Shaw; TT, Hong. In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium Handling Machinery and Cardiac Function. JACC, 2020.
I, Epifantseva; S, Xiao; RE, Baum; AG, Kleber; T, Hong; RM, Shaw. An Alternatively Translated Connexin 43 Isoform, GJA1-11k, Localizes to the Nucleus and Can Inhibit Cell Cycle Progression. Biomolecules, vol. 10, no. 3, 2020.
2019
RM, Shaw; JE, Saffitz. A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. J. Clin. Invest., vol. 130, no. 4, pp. 1608–1610, 2019.
RM, Shaw. Correlating Cardiac Origin Neurohormonal Stress Levels With Heart Failure Outcomes. JAMA Cardiol, 2019.
AP, Nikolova; T, Hong; RM, Shaw. Letter by Nikolova et al Regarding Article, ‘Heart failure with preserved ejection fraction in perspective. Circ. Res., vol. 125, no. 4, pp. e24-e25, 2019.
RH, Zadikany; T, Hong; RM, Shaw. Heart failure: distinguishing failing myocardium from volume overload. Biomark Med, vol. 13, no. 9, pp. 697–700, 2019.
T, Hong; RM, Shaw. Editorial commentary: Extracellular vesicles in cardiovascular diagnosis and therapy. Trends Cardiovasc. Med., vol. 29, no. 6, pp. 324–325, 2019.
2018
Epifantseva I, Shaw RM. Intracellular trafficking pathways of Cx43 gap junction channels. Biochim Biophys Acta Biomembr, vol. 1860, no. 1, pp. 40–47, 2018.
RM, Shaw; AP, Nikolova. The Clinical Course of a Genetic Dilated Cardiomyopathy: Letting the Cat Out of the BAG3. J. Am. Coll. Cardiol., vol. 72, no. 20, pp. 2482–2484, 2018.
Hitzeman TC; Nikolova AP, Baum R. Association of a Novel Diagnostic Biomarker, the Plasma Cardiac Bridging Integrator 1 Score, With Heart Failure With Preserved Ejection Fraction and Cardiovascular Hospitalization. JAMA Cardiol, vol. 3, no. 12, pp. 1206–1210, 2018.
Fu Y; Basheer WA, Shimura D. Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury. JCI Insight, vol. 3, no. 20, 2018.
Nikolova AP, Shaw RM. Editorial commentary: Are cytokines ready for prime time? Insights from markers and trials. Trends Cardiovasc. Med., vol. 28, no. 6, pp. 380–381, 2018.
RM, Shaw; AP, Nikolova. A Surprising Noncanonical Role for Calcineurin in Pressure-Induced Cardiac Hypertrophy. J. Am. Coll. Cardiol., vol. 71, no. 6, pp. 668–669, 2018.
2017
Hong T, Shaw RM. Cardiac T-Tubule Microanatomy and Function. Physiol. Rev., vol. 97, no. 1, pp. 227–252, 2017.
Y, Fu; RM, Shaw. CASAAV Technology to Examine Regulators of Heart Failure: Cause or Effect. Circ. Res., vol. 120, no. 12, pp. 1846–1848, 2017.
Fu Y; Xu B, Liu Y. The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles. PLoS Biol., vol. 15, no. 8, pp. e2002354, 2017.
Xiao S; Basheer WA, Epifantseva I. GJA1-20k Arranges Actin to Guide Cx43 Delivery to Cardiac Intercalated Discs. Circ. Res., vol. 121, no. 9, pp. 1069–1080, 2017.
Zhang SS; Fu Y, Xiao S. Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport. Front Physiol, vol. 8, pp. 905, 2017.
2016
RM, Shaw. Ion Channel Trafficking in the Heart. vol. 7/E, 2016.
T, Hong; RM, Shaw. Ion Channel Trafficking. Ion Channels in Health and Disease, 2016.
WA, Basheer; RM, Shaw. The ‘Tail’ of Connexin43: An Unexpected Journey from Alternative Translation to Trafficking. Biochimica et Biophysica Acta, vol. 1863, no. 1848-56, 2016.
Manning JR; Levitan BM, Withers CN. Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart. J Cardiovasc Transl Res, vol. 9, no. 5-6, pp. 432–444, 2016.
Basheer WA, Shaw RM. Cx43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium. Circ Arrhythm Electrophysiol, vol. 9, no. 6, pp. e001357, 2016.
2015
Xiao S, Shaw RM. Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention. Trends Cardiovasc. Med., vol. 25, no. 5, pp. 379–389, 2015.
Shaw RM; Chen-Izu Y, Pitt GS. Na+ channel function, regulation, structure, trafficking and sequestration. J. Physiol. (Lond.), vol. 593, no. 6, pp. 1347–1360, 2015.
Xiao S; Fu Y, Hong TT. Cytoskeleton regulation of ion channels. Circulation, vol. 131, no. 8, pp. 689–691, 2015.
2014
RM, Shaw. Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis. Dev. Cell, vol. 31, no. 2, pp. 139–140, 2014.
Hong SG; Zhang SS, Kléber AG; RM, Shaw. A micropatterning approach for imaging dynamic Cx43 trafficking to cell-cell borders. FEBS Lett., vol. 588, no. 8, pp. 1439–1445, 2014.
Yang H; Hong T, Zhang S. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat. Med., vol. 20, no. 6, pp. 624–632, 2014.
Zhang SS; Smyth JW, Sanchez JM. A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia. Traffic, vol. 15, no. 6, pp. 684–699, 2014.
Vesely ED; Schumacher-Bass SM, Zhang L. Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes. Circ. Res., vol. 114, no. 6, pp. 982–992, 2014.
SS, Zhang; RM, Shaw. Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization. Cell Commun. Adhes., vol. 21, no. 1, pp. 43–54, 2014.
2013
Ferrer T; Samson SC, Jou CJ. 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS Biol., vol. 11, no. 12, pp. e1001727, 2013.
JW, Smyth; RM, Shaw. Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Rep, vol. 5, no. 3, pp. 611–618, 2013.
RM, Shaw; HM, Colecraft. L-type calcium channel targeting and local signalling in cardiac myocytes. Cardiovasc. Res., vol. 98, no. 2, pp. 177–186, 2013.
SS, Zhang; RM, Shaw. Multilayered regulation of cardiac ion channels. Biochim Biophys Acta, vol. 1833, no. 876-85, 2013.
JR, Martens; RM, Shaw. Ion Channel Trafficking. 2013.
R, Cogswell; D, McGlothlin; E, Kobashigawa; R, Shaw; T, De Marco. Performance of the REVEAL model in WHO Group 2 to 5 pulmonary hypertension: application beyond pulmonary arterial hypertension. J Heart Lung Transplant, vol. 32, no. 293-8, 2013.
RM, Shaw. Reduced sodium channels in human ARVC. Heart Rhythm, vol. 10, no. 3, pp. 420–421, 2013.
Zhang L; Gao D, Dhillon R. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS ONE, vol. 8, no. 4, pp. e60967, 2013.
2012
Cogswell R; Hong TT, James CA; RM, Shaw. Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm, vol. 9, no. 6, pp. 961–967, 2012.
Smyth JW; Hong TT, Chu K; RM, Shaw. BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart Rhythm, vol. 9, no. 5, pp. 812–820, 2012.
R, Cogswell; E, Kobashigawa; D, McGlothlin; R, Shaw; T, De Marco. Validation of the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) pulmonary hypertension prediction model in a unique population and utility in the prediction of long-term survival. 2012.
LK, Svoboda; KG, Reddie; L, Zhang; ED, Vesely; ES, Williams; SM, Schumacher; RP, O’Connell; R, Shaw; SM, Day; JM, Anumonwo; KS, Carroll; JR, Martens. Redox-sensitive sulfenic acid modification regulates surface expression of the cardiovascular voltage-gated potassium channel Kv1.5. 2012.
Vogan J; Smyth JW, Buch P. Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circ. Res., vol. 110, no. 7, pp. 978–989, 2012.
JW, Smyth; RM, Shaw. The gap junction life cycle. Heart Rhythm, vol. 9, no. 1, pp. 151–153, 2012.
JW, Smyth; RM, Shaw. Visualizing cardiac ion channel trafficking pathways. Meth. Enzymol., vol. 505, pp. 187–202, 2012.
2011
Kim KH*; Zhang SS*, Rosen A*. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc. Natl. Acad. Sci. U.S.A., vol. 108, no. 33, pp. 13576–13581, 2011.
2010
RM, Shaw; Y, Rudy. Cardiac muscle is not a uniform syncytium. Biophys. J., vol. 98, no. 12, pp. 3102–3103, 2010.
JW, Smyth; RM, Shaw. Forward trafficking of ion channels: what the clinician needs to know. Heart Rhythm, vol. 7, no. 8, pp. 1135–1140, 2010.
Bussen M; Chi NC, Brand-Arzamendi K; DY, Stainier. Cardiac conduction is required to preserve cardiac chamber morphology. Proc. Natl. Acad. Sci. U.S.A., vol. 107, no. 33, pp. 14662–14667, 2010.
Smyth JW; Hong TT, Gao D; RM, Shaw. BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol., vol. 8, no. 2, pp. e1000312, 2010.
Hong TT; Smyth JW, Gao D. Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J. Clin. Invest., vol. 120, no. 1, pp. 266–279, 2010.
2009
Tsuchihashi T; Ieda M, Ivey KN; D, Srivastava. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev. Cell, vol. 16, no. 2, pp. 233–244, 2009.
2008
Fish JE; Saxena A, White MD. Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation, vol. 117, no. 17, pp. 2224–2231, 2008.
JW, Smyth; RM, Shaw. Visualizing ion channel dynamics at the plasma membrane. Heart Rhythm, vol. 5, no. 6 Suppl, pp. 7–11, 2008.
Shaw RM; Chi NC, Jungblut B; DY, Stainier. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol., vol. 6, no. 5, pp. e109, 2008.
RM, Shaw. Congestive Heart Failure. 2008.
Shaw RM; Chi NC, De Val S; DY, Stainier. Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev., vol. 22, no. 6, pp. 734–739, 2008.
2007
K, Chatterjee; Zhang J; N, Honbo; U, Simonis; RM, Shaw; and Karliner J. Acute vincristine pretreatment protects adult mouse cardiac myocytes from oxidative stress. JMCC, vol. 43, no. 327-36, 2007.
Fay AJ* Shaw RM*, Puthenveedu MA; LY, Jan. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell, vol. 128, no. 3, pp. 547–560, 2007.
2005
Shaw RM* Ionescu-Zanetti C*, Seo J; LP, Lee. Mammalian electrophysiology on a microfluidic platform. Proc. Natl. Acad. Sci. U.S.A., vol. 102, no. 26, pp. 9112–9117, 2005.
PJ, Lee; PJ, Hung; R, Shaw; L, Jan; LP, Lee. Microfluidic application-specific integrated device for monitoring direct cell-cell communication via gap junctions between individual cell pairs. App Phys Lett, vol. 86, no. 223902, 2005.
2000
RJ, Lee; ML, Springer; WE, Blanco-Bose; RM, Shaw; PC, Ursell; and Blau HM. VEGF gene delivery to myocardium: Deleterious effects of unregulated expression. Circulation, vol. 102, no. 898-901, 2000.
1999
Viswanathan PC, Shaw RM; Y, Rudy. Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation, vol. 99, no. 18, pp. 2466–2474, 1999.
1998
RM, Shaw; Y, Rudy. “Gap junctions and the spread of electrical current”. In: “Heart cell communication in health and disease. 1998.
1997
RM, Shaw; Y, Rudy. Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ. Res., vol. 81, no. 5, pp. 727–741, 1997.
RM, Shaw; Y, Rudy. Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc. Res., vol. 35, no. 2, pp. 256–272, 1997.
Y, Rudy; RM, Shaw. Membrane factors and gap-junction factors as determinants of ventricular conduction and reentry. 1997.
RM, Shaw; Y, Rudy. Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circ. Res., vol. 80, no. 1, pp. 124–138, 1997.
Y, Rudy; RM, Shaw. Cardiac excitation: an interactive process of ion channels and gap junctions. vol. 430, pp. 269–279, 1997.
1995
RM, Shaw; AT, Loomis; and Crisman E. Input and Integration: Enabling technologies for disabled users. 1995.
RM, Shaw; Y, Rudy. The vulnerable window for unidirectional block in cardiac tissue: characterization and dependence on membrane excitability and intercellular coupling. J. Cardiovasc. Electrophysiol., vol. 6, no. 2, pp. 115–131, 1995.
1992
LP, Clarke; SJ, Cullom; R, Shaw; C, Reece; BC, Penney; MA, King; M, Silbiger. Bremsstrahlung imaging using the gamma camera: Factors affecting attenuation. vol. 33, no. 161-6, 1992.